BRAF(V600E) Test for Suspicious Lateral Lymph Nodes in Papillary Thyroid Cancer.
10.16956/kjes.2016.16.2.36
- Author:
Wan Wook KIM
1
;
Hyang Hee CHOI
;
Jeeyeon LEE
;
Seung Ook HWANG
;
Ho Yong PARK
;
Ji Young PARK
;
Jin Hyang JUNG
Author Information
1. Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea. jjh01@knu.ac.kr
- Publication Type:Original Article
- Keywords:
BRAF(V600E) mutation;
Lymph node;
Metastasis;
Papillary thyroid cancer
- MeSH:
Biopsy, Fine-Needle;
Humans;
Lymph Nodes*;
Methods;
Neck Dissection;
Neoplasm Metastasis;
Sensitivity and Specificity;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Korean Journal of Endocrine Surgery
2016;16(2):36-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study evaluates the BRAF(V600E) test with fine-needle aspiration cytology (FNAC) for lateral lymph node (LN) metastasis in papillary thyroid carcinoma (PTC). METHODS: Ninety-one patients, including 95 lateral LNs with possible PTC metastasis, were consecutively entered into the study. We analyzed the accuracy of results for the BRAF(V600E) test and FNAC for lateral LN metastasis in PTC. RESULTS: Modified radical neck dissection was performed for 34 cases due to lateral LN metastasis. The sensitivity of FNAC was 88.2% , and the LN-BRAF(V600E) test 64.7%. The specificity and positive predictive value (PPV) were 100% for both tests. The negative predictive values (NPV) were FNAC, 93.8%, and LN-BRAF(V600E), 83.6%. For samples positive with either the BRAF(V600E) test or FNAC, the sensitivity was 94.1%, specificity 100%, PPV value 100%, and NPV 96.8%. CONCLUSION: This study suggests that the complementary LN-BRAF(V600E) test with FNAC is a supportive diagnostic method for PTC patients with indeterminate or non-diagnostic suspicious lateral LNs.
