Predictive analysis of quality markers of Forsythia suspensa based on fingerprint and network pharmacology
- VernacularTitle:基于指纹图谱和网络药理学的连翘质量标志物预测分析
- Author:
Fengtang JING
1
;
Shuai FENG
2
;
Jing WANG
3
;
Xuzhen LYU
1
;
Tianyi ZHANG
1
;
Tianxi ZHANG
1
;
Feng LI
1
Author Information
1. School of Pharmacy，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. School of Pharmacy，Shandong University of Traditional Chinese Medicine，Jinan 250355，China;Collaborative Innovation Center for Quality Control and Construction of Whole Industrial Chain for Traditional Chinese Medicine in Universities of Shandong Province，Jinan 250355，China
3. Dongying District Market Supervision and Administratio n Bureau in Dongying City，Shandong Dongy ing 257000，China
- Publication Type:Journal Article
- Keywords:
Forsythia suspensa;
quality marker;
fingerprint;
network pharmacology
- From:
China Pharmacy
2022;33(3):293-298
- CountryChina
- Language:Chinese
-
Abstract:
OBJ ECTIVE To predict the quality marker （Q-Marker）of Forsythia suspensa . METHODS The fingerprints of 10 batches of F. suspensa were established by high performance liquid chromatography. The common peaks were confirmed. The candidate components of Q-Marker in F. suspensa were screened. The volatile oil of F. suspensa were analyzed by gas chromatography-mass spectrometry （GC-MS），and the candidate components of Q-Marker in volatile oil were screened. The network pharmacology analysis was performed for the candidate components of Q-Marker. The network diagram of the “candidate components of F. suspensa Q-Marker-target-pathway”was constructed to predict the Q-marker of F. suspensa . RESULTS & CONCLUSIONS Twenty-one common peaks were obtained for 10 batches of F. suspensa ，and four components were identified as phillyrin，forsythoside A ，pinoresinol-4-O-β-D-glucoside and rutin. Seven candidate components were obtained by GC-MS analysis，such as β-pinene，α-pinene，terpinen-4-ol，limonene，γ-terpinene，α-phellandrene，β-myrcene. By network pharmacology analysis， 16 key targets and 17 pathways were obtained. It was preliminarily predicted that phillyrin ， forsythoside A ， pinoresinol-4-O-β-D-glucoside，rutin，terpinen-4-ol，α-phellandrene，α-pinene and β-pinene were Q-marker of F. suspensa .
