Advances in the regulation of type Ⅰ CRISPR system on biofilm formation and antibiotic resistance
10.3760/cma.j.cn114452-20200921-00740
- VernacularTitle:Ⅰ型CRISPR系统参与细菌生物膜形成与耐药调控的研究进展
- Author:
Lihua QI
1
;
Weihong FAN
;
Lu YAO
;
Jie LIU
Author Information
1. 解放军总医院第七医学中心检验科，北京100700
- Keywords:
Biofilms;
Clustered regularly interspaced short palindromic repeats;
Bacteria;
Drug resistance
- From:
Chinese Journal of Laboratory Medicine
2021;44(6):542-546
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, bacterial antibiotic resistance is becoming a huge threaten for human health. It′s getting even more serious after biofilm formation. In addition to physical and chemical factors such as barrier function and microenvironmental changes, the regulation of some genes in biofilm also specifically improves the level of antibiotic resistance. There might be a common regulatory mechanism between antibiotic resistance and the ability of biofilm formation. Type Ⅰ clustered regularly interspaced short palindromic repeats (CRISPR) system can affect the acquisition and spread of antibiotic resistance. The effect varies with species, evolution process and environmental pressure. Recently, it has been reported that type Ⅰ CRISPR system could not only regulate biofilm formation, but could also participate in the interaction between bacteriophages and biofilm. It might become a breakthrough point in the study of phage therapy. This article reviews the situation of antibiotic resistance in recent years, the new progress of biofilm-specific antibiotic resistance, and the effects of type Ⅰ CRISPR system on biofilm formation and antibiotic resistance, so as to provide new ideas for the prevention and treatment of bacterial infection.
