Advances in lipid metabolism during Chlamydia infection
10.3760/cma.j.cn112309-20201015-00476
- VernacularTitle:衣原体脂质代谢研究进展
- Author:
Lifang CHEN
1
;
Rongrong ZHANG
;
Tianjun JIA
Author Information
1. 河北北方学院病原生物学与免疫学研究所，张家口 075000
- Keywords:
Chlamydia;
Phospholipids;
Cholesterol
- From:
Chinese Journal of Microbiology and Immunology
2021;41(6):479-483
- CountryChina
- Language:Chinese
-
Abstract:
Chlamydia, a gram-negative obligate intracellular pathogen, is a major cause of human reproductive tract, eye and respiratory tract infections. It replicates in a special membrane-binding chamber called inclusion and survives in the host′s hostile intracellular environment through secreting effectors, but requires host-derived lipids to grow and develop in the cells. Emerging evidences suggest that Chlamydia has evolved a variety of strategies to meet its lipid needs by interacting with host cell compartments and redirecting the transport pathway to its intracellular niche. This paper briefly described the pathway for obtaining host lipids and the mechanism of lipid metabolic during Chlamydia infection.
