Analysis of de novo non-alcoholic fatty liver disease in early period after pediatric liver transplantation: a report of 8 cases
10.3760/cma.j.cn421203-20200728-00261
- VernacularTitle:儿童肝移植术后早期新发非酒精性脂肪性肝病八例临床分析
- Author:
Kai WANG
1
;
Chao SUN
;
Chong DONG
;
Weiping ZHENG
;
Yang YANG
;
Fubo ZHANG
;
Chao HAN
;
Hong QIN
;
Wei GAO
Author Information
1. 天津市第一中心医院儿童器官移植科 天津市器官移植重点实验室 300192
- Keywords:
Liver transplantation;
Child;
Graft;
Steatosis
- From:
Chinese Journal of Organ Transplantation
2021;42(9):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical characteristics of de novo non-alcoholic fatty liver disease(NAFLD)in pediatric recipients in early stage post liver transplantation(LT)to enhance our understanding of this rare complication.Methods:The clinical data of 8 recipients who underwent liver transplantation in the children's organ transplantation Department of Tianjin first central hospital from January 2014 to December 2019 and developed NAFLD within 3 months after operation were retrospectively analyzed. Taking liver biopsy as the standard for the diagnosis of NAFLD, the clinical and histological characteristics of early NAFLD after transplantation were summarized and analyzed.The median time from LT to NAFLD was 1.55(0.63, 2.93)months and the median follow-up period 23.60(8.74, 32.58)months.Results:NAFLD was all pathologically confirmed by liver biopsy. Seven cases had abnormal liver function and 1 case of steatosis was detected by ultrasound pre-biopsy. There were acute cellular rejection(2 cases)and drug-induced graft injury(1 case). The median period of recovery for graft function was 32.0(12.0, 34.0)days. Macrovesicular graft steatosis predominated.Conclusions:Occurring earlier in children after LT, NAFLD is frequently accompanied by abnormal graft function. Liver biopsy is required for making a definite diagnosis. Abnormal graft function persists a long time. However, prognosis is generally decent.
