Action mechanisms of thymic stromal lymphopoietin in various skin diseases
- VernacularTitle:胸腺基质淋巴细胞生成素在不同皮肤病中的作用机制研究
- Author:
Xinxing JIN
1
;
Sizhe LI
;
Yagang ZUO
Author Information
- Keywords: Interleukin-7; Dermatitis, atopic; Psoriasis; Pemphigoid, bullous; Netherton syndrome; Epidermolysis bullosa simplex; Skin neoplasms; Thymic stromal lymphopo
- From: Chinese Journal of Dermatology 2021;54(10):915-919
- CountryChina
- Language:Chinese
- Abstract: Thymic stromal lymphopoietin (TSLP) , a cytokine similar to interleukin-7 (IL-7) , can promote the differentiation and proliferation of a variety of cells, promote the secretion of Th2 cytokines by these cells, and plays an important role in the immune system. In recent years, abnormal expression of TSLP has been found in many skin diseases, and its level is also related to the severity of some skin diseases, suggesting that TSLP may be a potential target for the treatment of various skin diseases. This review summarizes recent research progress in the role of TSLP in the occurrence and development of various skin diseases, including inflammatory diseases, immune diseases, genetic diseases and tumors, and provides a basis and some ideas for the diagnosis and treatment of related diseases.
