Analysis of seven cases of multiple myeloma with initial manifestation of bleeding
10.3760/cma.j.cn112138-20200828-00780
- VernacularTitle:出血为首发症状的多发性骨髓瘤七例分析
- Author:
Caifang ZHAO
1
;
Huixian HU
;
Li CHEN
;
Lili WANG
;
Bin WEI
;
Han XU
Author Information
1. 浙江大学医学院附属金华医院 金华市中心医院血液科，浙江省金华市 321000
- Keywords:
Multiple myeloma;
Factor Ⅶ deficiency;
Factor X deficiency;
Clinical research
- From:
Chinese Journal of Internal Medicine
2021;60(9):831-833
- CountryChina
- Language:Chinese
-
Abstract:
A retrospective analysis of 7 patients of multiple myeloma (MM) with initial manifestation of bleeding and coagulation abnormalities were performed. Clinical manifestations, laboratory and imaging examinations were collected. The activity of coagulation factors was measured before the treatment. Single factor X deficiency was seen in one patient. Two cases had factor Ⅶ deficiency, while four other patients had multiple factor deficiency. The time from onset of symptoms to diagnosis ranged from 2 to 10 months. After anti-MM treatment started and plasma or coagulation factors were transfused, the prolonged coagulation time returned to normal from 28-84 days. Most of these patients presented large, deep and multiple sites of hematoma, which caused concerns of bone marrow puncture and may direct to other differential diagnoses. This is helpful to improve physicians′ understanding of the special clinical characteristics in MM patients.
