The research advance and role of neutrophils in the occurrence and development of renal cell carcinoma
10.3760/cma.j.cn112330-20210414-00195
- VernacularTitle:中性粒细胞在肾癌发生发展中的作用及其研究现状
- Author:
Ruiyang XIE
1
;
Jianzhong SHOU
Author Information
1. 国家癌症中心/国家肿瘤临床医学中心/中国医学科学院 北京协和医学院肿瘤医院泌尿外科，北京 100021
- Keywords:
Carcinoma, Renal cell;
Neutrophil;
Neutrophil extracelluar traps;
Drug treatments
- From:
Chinese Journal of Urology
2021;42(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma is a common malignant tumor of the urinary system. The immune microenvironment to which neutrophils belong has a dual role of suppressing and promoting the development of renal cell carcinoma. The cancer-promoting effects through mechanisms such as mediating inflammation, expressing chemokines, and generating neutrophil extracelluar traps have become research hotspots. Targeted drugs and immune checkpoint inhibitors are used as systemic treatments for patients with advanced renal cell carcinoma. Their efficacy and prognosis are related to neutrophil activity. The neutrophil infiltration in tumor and peripheral blood neutrophil level increase suggest the poor prognosis of patients with renal cell carcinoma. The phenotype and function of neutrophils can be affected by inflammation associated with renal cell carcinoma, and the high expression of CXC chemokines leads to poor prognosis. In addition, the neutrophil extracellular traps can capture tumour cells in the peripheral blood and assist their survival and migration.
