Research progress on the mechanisms of restless legs syndrome in patients with Parkinson's disease

VernacularTitle:帕金森病共病不宁腿综合征机制的研究进展
Author: Shuyu SUN ¹ ; Xianchao ZHAO ; Jian QIU ; Jinxiang CHENG ; Changjun SU
Author Information

1. 空军军医大学第二附属医院神经内科，西安　710038
Keywords: Parkinson disease; Restless legs syndrome; Dopamine
From: Chinese Journal of Geriatrics 2021;40(7):921-925
CountryChina
Language:Chinese
Abstract: Parkinson's disease(PD)and restless legs syndrome(RLS)are relatively common movement disorders.There has been much debate over whether an etiological link exists between these two diseases and whether they share common pathophysiological mechanisms.PD and RLS may co-occur and respond well to dopaminergic agents, suggesting there is underlying dopamine dysfunction in both conditions.Despite the overlapping clinical features, the mechanisms underlying idiopathic RLS and RLS associated with PD may differ.In this article, we review studies related to the epidemiology, pathophysiology and genetics of PD with concurrent RLS, in order to provide evidence for exploring the link between RLS and PD.