Correlation analysis of chronic obstructive pulmonary disease with inositol 1, 4, 5-trisphosphate 3-kinase C and phospholipase c-like 1 gene polymorphisms in elderly population
10.3760/cma.j.issn.0254-9026.2021.07.008
- VernacularTitle:老年人慢性阻塞性肺疾病与1，4，5-三磷酸肌醇3激酶C和磷脂酶C样1蛋白基因多态性的相关性
- Author:
Xinyun XIE
1
;
Xi WANG
;
Bing ZHUAN
;
Qun YUAN
;
Ping LI
;
Jun XIE
;
Zhao YANG
Author Information
1. 西北民族大学第一附属医院 宁夏回族自治区人民医院院本部呼吸内科，银川 750011
- Keywords:
Pulmonary disease, chronic obstructive;
Hypertension pulmonary;
Polymorphism, single nucleotide
- From:
Chinese Journal of Geriatrics
2021;40(7):853-858
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations of stable chronic obstructive pulmonary disease(COPD)with inositol 1, 4, 5-trisphosphate 3-kinase C(ITPKC)and phospholipase C-like 1 protein(PLCL1)single nucleotide polymorphisms(SNPs)in the Han elderly population in Ningxia.Methods:A case-control study was conducted.A total of 250 elderly patients with stable COPD were enrolled and divided into the COPD-related pulmonary hypertension(PH)group(n=103)and the COPD non-PH group(n=147). During the same period, 127 healthy elderly Han subjects were included as the control group.The ITPKC gene SNPs and the PLCL1 gene SNP were detected, and differences in alleles and genotype frequencies were compared between the groups.Results:The allele and genotype frequency distributions of rs2288450 and rs9789480 showed statistical differences between the COPD group and the control group(χ 2=6.09, 5.18, 30.14 and 32.89, P=0.048, 0.020, <0.001, <0.001). There was no difference in the allele and genotype frequency distributions of the ITPKC gene SNPs rs2290692 and rs17713068 between the control group and the COPD group(all P>0.05). The allele and genotype frequency distributions of rs9789480 showed differences between the COPD non-PH group and the COPD-PH group(χ 2=94.50 and 72.76, both P<0.001). There was no significant difference in the allele and genotype frequency distributions of rs2290692, rs17713068, rs2288450 between the COPD-PH group and the COPD non-PH group(all P>0.05). Conclusions:The ITPKC gene SNP rs2288450 CA and AA genotypes and A allele can reduce the incidence of COPD and may be a protective factor for COPD in the elderly.The PLCL1 gene SNP rs9789480 CA and AA genotypes and A allele can reduce the incidence of COPD and COPD-PH and may be a protective factor for COPD and COPD-PH in the elderly.
