Research progress of mesenchymal stem cells and exosomes derived from them in the treatment of osteoporosis
10.3760/cma.j.cn121113-20210227-00207
- VernacularTitle:间质干细胞及其来源的外泌体在骨质疏松症治疗中作用的研究进展
- Author:
Jiaming YANG
1
;
Jiahong ZHANG
;
Qinqin LIU
;
Yanlong NIU
;
Maoyuan WANG
Author Information
1. 赣南医学院，赣州 341000
- From:
Chinese Journal of Orthopaedics
2021;41(23):1726-1734
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis seriously threatens the living quality of people, especially the elderly, and causes a huge economic burden to society. In the past, bisphosphonates, denosumab and other first-line drugs were used in the treatment of osteoporosis. However, these drugs can only inhibit bone resorption, but can not promote bone formation. Studies have shown that mesenchymal stem cells (MSCs) can be used to treat osteoporosis, however, it has some defects and deficiencies, such as genetic instability, limited cell survival and increased risk of cancer. However, mesenchymal stem cell-derived exosomes (MSCs-Exos) can regulate the differentiation and proliferation of osteoblasts by mediating wingless and int-1 (Wnt)/β-catenin and mitogen-activated protein kinase (MAPK) signaling pathways, promote bone regeneration, and thus has an impact on osteoporosis. In this paper, preclinical studies on MSCs and MSCs-Exos in the treatment of osteoporosis in recent years were reviewed, in order to provide a new idea for the treatment of osteoporosis.
