Research progress on hippocampal-avoidance whole brain radiotherapy

VernacularTitle:海马区保护性全脑放疗研究进展
Author: Mengyuan CHEN ¹ ; Yuanyuan CHEN ; Ming CHEN ; Xianghui DU
Author Information

1. 中国科学院肿瘤与基础医学研究所　中国科学院大学附属肿瘤医院放疗科　浙江省肿瘤医院放疗科，杭州　310000
Keywords: Neoplasm brain metastases/hippocampal-avoidance whole brain radiotherapy; Neurocognitive function; Research progress
From: Chinese Journal of Radiation Oncology 2021;30(7):735-738
CountryChina
Language:Chinese
Abstract: With the advancement of imaging diagnosis and the development of modern radiotherapy, the survival of cancer patients has been prolonged and the incidence rate of brain metastases (BM) has been significantly increased. The quality of life of patients and potential radiotherapy-induced neurocognitive impairment have gradually captivated widespread attention. Whole brain radiotherapy (WBRT) is one of the common local therapies for BM patients. However, the application of WBRT is controversial because it may lead to neurocognitive impairment. The incidence of metastatic tumors in hippocampus and radiation-induced neurocognitive impairment can accelerate the implementation of hippocampal-avoidance WBRT (HA-WBRT). In this article, the feasibility of HA-WBRT was discussed and research progress in recent years was reviewed.