Hereditary effects of ionizing radiation-a review of human epidemiological studies
10.3760/cma.j.issn.0254-5098.2021.09.014
- VernacularTitle:电离辐射遗传效应的人群流行病学研究现状
- Author:
Yu GAO
1
;
Yumin LYU
;
Quanfu SUN
Author Information
1. 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室，北京 100088
- Keywords:
Ionizing radiation;
Hereditary effect;
Birth defect;
Cancer;
Human genome
- From:
Chinese Journal of Radiological Medicine and Protection
2021;41(9):716-720
- CountryChina
- Language:Chinese
-
Abstract:
Parental exposure to ionizing radiation (IR) can induce mutation in germline that may lead to genome instability, chromosomal aberrations, sex ratio variations, increased cancer susceptibility, and even increased probability of birth defects among their offspring, which substantially increase the burden of hereditary diseases. Up to now, the hereditary effect of IR has been observed in a number of species, but there is lack of evidence in humans. With reference to related studies in China and globally, this article reviews the human epidemiological studies of the hereditary effect of IR and briefly discusses why the hereditary effect of IR is not obvious in humans, so as to provide a reference for future assessment of the hereditary effect of radiation in China.
