Progress in the treatment of radiation-induced pulmonary fibrosis with mesenchymal stem cells

VernacularTitle:间充质干细胞治疗放射性肺纤维化的研究进展
Author: Wenyue ZHAO ¹ ; Liqing DU ; Qiang LIU
Author Information

1. 中国医学科学院北京协和医学院放射医学研究所，天津　300192
Keywords: Radiation-induced pulmonary fibrosis; Mesenchymal stem cells; Stem cell therapy
From: Chinese Journal of Radiological Medicine and Protection 2021;41(4):309-314
CountryChina
Language:Chinese
Abstract: Radiation-induced pulmonary fibrosis (RIPF) is a common complication of thoracic tumor radiotherapy. The main manifestation of radiation-induced pulmonary fibrosis is chronic progressive consolidation of pulmonary interstitium, which may cause the lung physiology function reduced or even lost. Furthermore, it can be lethal forrespiratory failure in severe cases. Recent studies have found that mesenchymal stem cells (MSC) play an important role in the modulation of proliferation and the activation of immune cells in lung inflammation. In addition, MSC can also play a part in the treatment of RIPF by differentiating into functional cells and secreting cytokines. Therefore, MSC has a good application prospect in RIPF as a cell therapy method. This article reviews the molecular mechanisms, influencing factors and current status of MSC therapy in RIPF.