Value of subtypes of antimitochondrial antibodies in primary biliary cholangitis
10.3760/cma.j.cn141217-20210311-00096
- VernacularTitle:抗线粒体抗体亚型与原发性胆汁性胆管炎的临床分析
- Author:
Hongyan YANG
1
;
Liling ZHAO
;
Shulan ZHANG
;
Zhaojun HU
;
Xiaofeng ZENG
;
Fengchun ZHANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科（教育部重点实验室 国家皮肤与免疫疾病临床研究中心）100730
- Keywords:
Cholangitis;
Antimitochondrial antibody;
Protein Isoforms
- From:
Chinese Journal of Rheumatology
2021;25(8):525-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution and clinical significance of subtypes of antimitochondrial antibodies (AMA)-M2, M4, M9 in primary biliary cholangitis (PBC).Methods:A total of 1 367 patients were detected with AMA-M2, M4, M9 in Peking Union Medical College Hospital (PUMCH) from Jan 2014 to Dec 2019 and the clinical parameters were collected. The distribution patterns of AMA subtypes in different groups were analyzed and the diagnostic sensitivity and specificity of AMA subtypes in PBC were calculated. Chi-square test was used for statistical analysis.Results:In 1 367 patients, 236 of whom were positive for AMA subtypes. The positivity of AMA subtypes in female was significantly higher than in male (20.34% vs 9.41%, χ2=23.792, P<0.01). In addition, the positivity of AMA subtypes was significantly higher in 30-65 years old patients than in patients younger than 30 years old or older than 65 years old [(20.00%(193/965) vs 10.97%(17/155) vs 10.53%(26/247), χ2=17.209, P<0.01]. 110 patients with positive AMA subtypes were diagnosed with PBC. The diagnostic sensitivity and specificity of AMA-M2 were both desirable [94.64%(106/112) and 92.35%(1 159/1 255)]. Although the specificity of AMA-M4 was as high as 99.12%(1 244/1 255), its sensitivity was very low [15.18%(17/122)]. Combined detection of different AMA subtypes could not improve the diagnostic sensitivity and specificity significantly. Diseases other than PBC can be positive for AMA subtypes, predominantly for AMA-M2. Conclusion:Female and 30-65 years old patients were more frequently positive for AMA subtypes. AMA-M2 was the most valuable AMA subtype for diagnosing PBC.
