The value of microvascular flow imaging method for the evaluation of placenta perfusion and prediction of fetal growth restriction: a pilot study
10.3760/cma.j.cn131148-20210221-00120
- VernacularTitle:超声微血管成像评价胎盘灌注与胎儿生长发育关系的初步研究
- Author:
Zihan NIU
1
;
Peipei ZHANG
;
Xining WU
;
Yuxin JIANG
;
Yunshu OUYANG
;
Hua MENG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院超声医学科 100730
- Keywords:
Ultrasonography;
Microvascular flowing imaging;
Placenta;
Fetal growth restriction
- From:
Chinese Journal of Ultrasonography
2021;30(8):691-696
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the placental micro-vascular circulation by microvascular flowing imaging (MVFI) method, and to explore the clinical value of microvascular index (MVI) for the diagnosis of fetal growth restriction (FGR).Methods:A total of 21 fetuses at 24-34 weeks of gestation at the Peking Union Medical College Hospital from October to November 2019 were enrolled in this study, including 7 fetal growth restriction (FGR) fetuses, and 14 normal fetuses as control group. The fetuses of the two groups were matched according to the gestational weeks at the ratio of 1∶2. Fetal biometry parameters were measured and the placenta was observed by two-dimensional ultrasound.Uterine artery pulse index (UtA-PI), middle cerebral artery pulse index (MCA-PI), and umbilical artery S/D ratio were evaluated by color and pulse-wave Doppler. The placenta mico-circulation was displayed by the MVFI method and MVI was measured.Results:The study included 14 normal fetuses and 7 FGR fetuses. Compared with the control group, more placenta in the FGR group manifested as thickened and heterogeneous with decreased MVI and increased UtA-PI. There was statistically significant difference in placental mean MVI between two groups ( P=0.044). Besides, a trend towards significant negative correlation was observed between MVI and placenta thickness, although this was not statistically significant ( rs=-0.35, P=0.065). MVI had a higher specificity (100%) in the prediction of FGR. Conclusions:MVFI can display the micro-circulation of the placenta, and provide a direct and quantitative assessment method for placental perfusion.
