Research progress in mechanism of pyroptosis mediated by inflammasomes and its targeted drugs after traumatic brain injury
10.3760/cma.j.cn501098-20200924-00613
- VernacularTitle:创伤性脑损伤后炎性小体介导细胞焦亡作用机制及靶向治疗药物研究进展
- Author:
Jinwei ZHANG
1
;
Yanjie JIA
Author Information
1. 郑州大学第一附属医院神经内科 450052
- Keywords:
Brain injuries;
Molecular targeted therapy;
Pyroptosis
- From:
Chinese Journal of Trauma
2021;37(3):278-283
- CountryChina
- Language:Chinese
-
Abstract:
After traumatic brain injury(TBI), as an immune signal complex in cytoplasm, the assembly and activation of inflammasomes can induce pyroptosis, trigger extensive inflammations, aggravate brain tissue damage, lead to delayed cell death and progressive neurodegeneration, and cause neurological dysfunction, which plays a key role in the development and prognosis of the disease. After TBI, the mechanism of pyroptosis mediated by inflammasomes and its targeted treatments have become the focus of recent researches. The authors review the research progress in inflammasomes-mediated pyroptosis in terms of related signal pathways, their activation and regulation and application of targeted drugs after TBI, so as to provide references for clinical treatments.
