Progress in molecular mechanism and clinical application of primordial follicle activation

VernacularTitle:原始卵泡激活的分子机制及临床应用进展
Author: Chunhui ZHANG ¹ ; Chenhong WANG ; Weiping QIAN
Author Information

1. 北京大学深圳医院生殖医学中心，北京大学深圳医院广东省生殖与遗传重点实验室　518036
Keywords: Primordial follicle activation; Primary ovarian insufficiency; Decreased ovarian reserve
From: Journal of Chinese Physician 2021;23(9):1281-1285
CountryChina
Language:Chinese
Abstract: With the continuous elucidation of the molecular mechanism of primordial follicle activation, clinical in vitro activation (IVA) has gradually become a clinical treatment for premature ovarian insufficiency (POI) and reduced ovarian reserve (DOR). This article will review the mechanism of phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3-kinase (PI3K), hippo signal and mammalian target of rapamycin complex 1 (mTORC1) signal involved in the activation of primordial follicles, and the application of IVA in patients with POI and DOR.