Research progress of T-type calcium channel in cancer

VernacularTitle:T型钙通道在肿瘤中的研究进展
Author: Gang FAN ¹ ; Jinglei ZANG ; Jiang CHEN ; Zhihong XIAO ; Yu XIE
Author Information

1. 华中科技大学协和深圳医院泌尿外科　518060
Keywords: Calcium channels, T-type; Neoplasms; Cell proliferation; Apoptosis
From: Journal of Chinese Physician 2021;23(8):1266-1269
CountryChina
Language:Chinese
Abstract: In most non-excited cells, voltage-gated T-type calcium channels present three properties of activation, inactivation and slow inactivation, thus contribute to cellular calcium signaling and membrane potential. By which T-type calcium channels play an important role in many cancer cellular processes such as cell proliferation, differentiation, apoptosis, invasion, and metastasis. Inhibiting T-type calcium channels by drugs or genetic tools can change the related cellular currents and the intracellular Ca 2+ , thereby regulating the biological tumorigenesis. This article reviews the electrophysiological of T-type calcium channels during tumor progression, aims to provide a scientific basis for the study and treatment in cancer.