Progress on the effect of mesenchymal stem cell derived exosomes on multiple organ dysfunction in sepsis

VernacularTitle:间充质干细胞外泌体在脓毒症多器官功能障碍中作用的研究进展
Author: Qian PU ¹ ; Guanghui XIU ; Jie SUN ; Ping LIU ; Bin LING
Author Information

1. 昆明医科大学第四附属医院（云南省第二人民医院）重症医学科，云南昆明　650021
Keywords: Mesenchymal stem cell; Exosomes; Sepsis; Organ dysfunction; MicroRNA
From: Chinese Critical Care Medicine 2021;33(6):757-760
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cell derived (MSC) exosomes are extracellular vesicles with a diameter of about 50-200 nm. Exosomes contain a large number of biologically active substances including mRNAs, miRNAs, cytokines, chemokines, proteins, lipids, etc. MSC exosomes exert biological effects through paracrine and endocrine pathways in vivo. Uncontrolled inflammation and multiple organ dysfunction are the key roles in the progression of sepsis, moreover, heart, lungs, kidneys and brain are the general target organs to be damaged. MSC exosomes regulate the expression of cytokines, the production of inflammatory cell, the levels of inflammatory response and the recovery of damaged tissues or organ function. Therefore, studying the application of MSC exosomes is significant for the clinical treatment of sepsis. This article reviews the systemic inflammation regulation by MSC exosomes and its protective function on targeted organs such as heart, lungs, kidneys, brain, liver, etc. to provide evidences for the treatment of sepsis.