Correlation between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and diabetic nephropathy
10.3760/cma.issn1008-6706.2021.12.002
- VernacularTitle:中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值与糖尿病肾病的相关性研究
- Author:
Aidan GU
1
;
Jinlan WU
;
Huaizhong XU
;
Jian GUAN
;
Yang XU
Author Information
1. 苏州高新区人民医院内分泌科 215219
- Keywords:
Diabetes mellitus, type 2;
Diabetic nephropathies;
Granulocytes;
Lymphocytes;
Blood platelets;
Risk factors;
Early diagnosis;
Forecasting
- From:
Chinese Journal of Primary Medicine and Pharmacy
2021;28(12):1767-1770
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To correlate neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with diabetic nephropathy (DN).Methods:A total of 160 patients with type 2 diabetes mellitus (T2DM) who received treatment between January 2017 and October 2020 in People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone were included in this study. These patients were randomly divided into DN [urinary albumin-to-creatinine ratio (UACR) ≥ 30 μg/mg, n = 85) and non-DN (UACR < 30 μg/mg, n = 75)] groups according to UACR values. A total of 150 healthy controls who concurrently received health examination were included in the control group. The clinical data and biochemical indicators were collected in each group and their clinical characteristics were compared. The factors that affect DN were analyzed using a logistic regression model. Results:Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with T2DM were (2.14 ± 1.12) and (175.00 ± 56.21), respectively, which were significantly higher than those in the healthy controls [(1.53 ± 0.29), (142.70 ± 37.25), t = 3.584, 5.642, both P < 0.05). NLR and PLR in the DN group were (2.64 ± 1.22) and (278.00 ± 72.23), respectively, which were significantly higher than those in the non-DN group [(1.80 ± 0.90), (193.00 ± 62.40), t = 2.738, 3.166, both P < 0.05)]. Logistic regression analysis showed that NLR and PLR are the risk factors of DN ( OR = 5.981, 1.807; 95% CI = 2.104-15.563, 1.327-2.795). Conclusion:Combined detection of NLR and PLR in the clinic may help early prediction of DN.
