Efficacy of arthroscopic debridement followed by imrecoxib combined with sodium aescinate application in the treatment of knee osteoarthritis
10.3760/cma.j.issn.1008-6706.2021.06.020
- VernacularTitle:艾瑞昔布联合七叶皂苷钠辅助关节镜清理术治疗膝骨关节炎的疗效分析
- Author:
Hongjun XU
1
;
Changming XU
;
Zheng WU
;
Rui JIANG
Author Information
1. 江苏省涟水县人民医院骨外科 223400
- Keywords:
Arthroscopy;
Osteoarthritis, knee;
Inflammation;
Pain;
Anti-inflammatory agents, non-steroidal;
Drug therapy,combination;
Range of motion,articular;
Interleu
- From:
Chinese Journal of Primary Medicine and Pharmacy
2021;28(6):895-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of arthroscopic debridement followed by imrecoxib combined with sodium aescinate application in the treatment of knee osteoarthritis.Methods:Ninety patients with knee osteoarthritis who received treatment in Lianshui County People's Hospital, China between February 2019 and February 2020 were included in this study. They were randomly assigned to receive imrecoxib treatment (control group A, n = 30), sodium aescinate treatment (control group B, n = 30) or imrecoxib combined with sodium aescinate treatment (observation group, n = 30). The clinical efficacy of different treatment strategies was compared. Results:Total effective rate in the observation group [93.33% (28/30)] was significantly higher than that in the control group A [70.0% (21/30)] and control group B [76.67% (23/30)] ( χ2 = 9.615, P < 0.05). In the observation group, postoperative pain and knee joint inflammation were more greatly mitigated, and knee joint function was better recovered compared with the control groups A and B ( F = 4.124, 3.895, 4.879, all P < 0.05). In the observation group, interlekin-1 level was significantly lower and interleukin-1β was significantly higher than those in the control groups A and B ( F = 3.423, 2.362, all P < 0.05). Conclusion:Arthroscopic debridement followed by imrecoxib combined with sodium aescinate application in the treatment of knee osteoarthritis has a positive effect on postoperative knee joint function recovery, comfort and reduction of inflammatory factors, which deserves clinical popularization.
