Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection
- Author:
Jiang CONGSHAN
1
;
Li XIAOWEI
;
Ge CHANGRONG
;
Ding YUANYUAN
;
Zhang TAO
;
Cao SHUAI
;
Meng LIESU
;
Lu SHEMIN
Author Information
1. Institute of Molecular and Translational Medicine (IMTM);Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center,76 West Yanta Road,Xi'an,Shaanxi,710061,PR China;Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University),Ministry of Education,Xi'an,Shaanxi,710061,PR China
- Keywords:
SARS-CoV-2;
Virus variation;
Nucleic acid detection;
Asymptomatic infection
- From:
Journal of Pharmaceutical Analysis
2021;11(3):257-264
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year.With the expanding second wave of the pandemic in winter,the continuous evolution of SARS-CoV-2 has brought new issues,including the significance of virus mutations in infection and the detection of asymptomatic infection.In this review,we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19,primarily focusing on their strengths and limitations.We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection.The review finally sum-marized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.
