Clinical features of Kawasaki disease shock syndrome and analysis of interleukin-6 expression levels
10.3760/cma.j.issn.1673-4912.2021.08.008
- VernacularTitle:川崎病休克综合征的临床特征及血清白细胞介素-6表达水平分析
- Author:
Le MA
1
;
Haiguo YU
Author Information
1. 南京医科大学附属儿童医院风湿免疫科 210000
- Keywords:
Kawasaki disease;
Kawasaki disease shock syndrome;
Interleukin-6
- From:
Chinese Pediatric Emergency Medicine
2021;28(8):679-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Kawasaki disease shock syndrome(KDSS) is a serious complication of Kawasaki disease(KD). The main manifestations are low blood pressure and decreased blood perfusion at the acute stage of onset, which is life-threatening.The purpose of this study was to provide early intervention and reduce the complications and mortality of this disease by analyzing clinical features and expression level of interleukin-6(IL-6)of children with KDSS.Methods:In this study, a total of 25 children with KDSS in Nanjing Children′s Hospital were collected, and their clinical characteristics, relevant laboratory indicators and IL-6 expression levels were analyzed by retrospective case-control study.Results:Compared with ordinary KD children, KDSS children were more common in older children, with prolonged fever, severe skin rash, high inflammatory indicators, and more likely to be associated with coronary dilatation.The level of IL-6 in children with KDSS in the acute phase was significantly higher than that in children with KD[(28.5±39.2) ng/mL vs.(226.8±102.9) ng/mL, P<0.05], while the level of IL-6 in children with KDSS in the convalescent period was significantly lower than that in the acute phase of KDSS[(226.8±102.9) ng/mL vs.(5.6±1.7)ng/mL, P<0.05], and the difference was statistically significant. Conclusion:The systemic inflammatory response of KDSS is more obvious, IL-6 plays an important role in it, and the therapeutic effect of IL-6 blocker in KD and its complications needs further study.
