Analysis of influencing factors of acute bilirubin encephlopathy in neonates with severe hyperbilirubinemia
10.3760/cma.j.issn.1673-4912.2021.06.015
- VernacularTitle:重度新生儿高胆红素血症并发急性胆红素脑病的影响因素分析
- Author:
Yangyang TU
1
;
Lu LIU
;
Xinhui YUAN
;
Yuning LI
Author Information
1. 兰州大学第一临床医学院 730000
- Keywords:
Hyperbilirubinemia;
Neonate;
Risk factors;
Protcctive factors;
Acute bilirubin encephalopathy
- From:
Chinese Pediatric Emergency Medicine
2021;28(6):516-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the influencing factors of acute bilirubin encephalopathy (ABE) in neonates with severe hyperbilirubinemia.Methods:A total of 123 cases of severe neonatal hyperbilirubinemia (serum total bilirubin > 342 μmol/L) in our hospital from January 2018 to May 2020 were retrospectively analyzed.According to the occurrence of ABE, they were divided into ABE group (28 cases) and non-ABE group (95 cases). The perinatal data and laboratory examination results between two groups were compared.The variables with statistical differences in univariate analysis were included in multivariate Logistic regression analysis.Results:Univariate analysis showed that the hemoglobin level and hematocrit of ABE group were higher than those of non-ABE group.The total bilirubin value, length of hospital stay, natural childbirth, mixed feeding, infection with craniocerebral hemorrhage were all higher than those in the non-ABE group, and the differences were statistically significant( P<0.05). Multivariate Logistic regression analysis showed that high hemoglobin level ( OR=1.032, 95% CI 1.007 to 1.057) and long hospital stay ( OR=1.15, 95% CI 1.007 to 1.312) were independent risk factors for ABE patients.Breastfeeding was a protective factor for ABE patients( OR=0.151, 95% CI 0.028 to 0.821). Conclusion:High hemoglobin value and long hospital stay are independent risk factors for ABE patients, and breast feeding is a protective factor for ABE.
