Research on the anti-lung cancer effects of targeted Neddylation modifying pathway and its inhibitor MLN4924 and its mechanism

VernacularTitle:靶向Neddylation修饰通路及通路抑制剂MLN4924的抗肺癌作用及其机制研究
Author: Feng ZHU ¹ ; Shiwen WANG ; Jingrong XIAN ; Yue LIU ; Hu ZHAO ; Yanmei ZHANG
Author Information

1. 复旦大学附属华东医院检验科　200040
Keywords: Lung neoplasms; Molecular targeted therapy; Neddylation
From: Journal of International Oncology 2021;48(9):564-567
CountryChina
Language:Chinese
Abstract: Neddylation is overactivated in lung cancer, which promotes the development of lung cancer by activating its downstream CRL ubiquitin ligase and promoting the CRL tumor-suppressor protein substrate degradation. MLN4924, a small molecule inhibitor of Neddylation, plays an anti-lung cancer role by inducing cell cycle arrest, apoptosis and senescence. Furthermore, targeting the key enzymes of Neddylation and their substrates, Cullin family proteins, can inhibit the development of lung cancer.