Correlation between PD-L1 and Tregs in tumor immunity and immunotherapy

VernacularTitle:PD-L1与Treg在肿瘤免疫及治疗中的相关性
Author: Huiyi OU ¹ ; Yue WANG ; Chenghong PENG
Author Information

1. 上海交通大学医学院附属瑞金医院外科胰腺中心　200025
Keywords: Tumor escape; T-lymphocytes, regulatory; PD-1/PD-L1; Immunotherapy
From: Journal of International Oncology 2021;48(6):350-353
CountryChina
Language:Chinese
Abstract: Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are important co-inhibitory molecules, while regulatory T cells (Tregs) are important suppressor cells. The increase of them in tumor microenvironment is closely related to tumor immune escape and tumor development. PD-L1 plays an important role in the development and function of Tregs. The application of PD-1/PD-L1 blockade also affects the proliferation and function of Tregs, which further participates in the occurrence of drug resistance and hyperprogressive disease. Further understanding of the role and correlation of PD-L1 and Tregs in tumor immunity and immunotherapy can provide new ideas for improving the efficacy of PD-1/PD-L1 blockade.