DNA damage repair and cell cycle arrest
10.3760/cma.j.cn121382-20210205-00414
- VernacularTitle:DNA损伤修复与细胞周期阻滞
- Author:
Mingxin DONG
1
;
Xiaohui SUN
;
Chang XU
;
Qiang LIU
Author Information
1. 中国医学科学院 北京协和医学院放射医学研究所，天津 300192
- Keywords:
Damage;
DNA repair;
DNA breaks, double-stranded;
Cell cycle arrest;
G1/S/G2 checkpoint
- From:
International Journal of Biomedical Engineering
2021;44(4):329-333,339
- CountryChina
- Language:Chinese
-
Abstract:
In the face of DNA damage caused by various factors, cells have a set of response and repair mechanisms. Cell cycle arrest plays an important role in the DNA damage repair, which provides enough time for repairing damaged DNA. Research on cell cycle regulation focuses on cyclin-dependent protein kinases (CDKs) and cell cycle checkpoints. In the process of DNA damage repair, phosphatidylinositol-3-kinase like kinases (PIKKs) which are recruited to the DNA damage sites can activate cell cycle checkpoint-related proteins to halt cell cycle. In the common DNA damage repair pathways, such as base excision repair (BER), nucleotide excision repair (NER) , mismatch repair (MMR) , and DNA double-strand break repair, the recruitment of repair-related proteins also plays a role in the cell cycle regulation. In this paper, the relationship between the main forms of DNA damage repair and cell cycle arrest and relevant research progress were reviewed.
