Pathophysiological mechanism of vascular cognitive impairment
10.3760/cma.j.issn.1673-4165.2021.08.010
- VernacularTitle:血管性认知损害的病理生理学机制
- Author:
Rui SUN
1
;
Ge YIN
;
Meng LIANG
;
Cunxiu FAN
;
Xiutian ZHANG
;
Xiaoying BI
Author Information
1. 中国人民解放军海军军医大学第一附属医院神经内科，上海 200433
- Keywords:
Cognition disorders;
Cerebrovascular disorders;
Dementia, vascular;
Blood-brain barrier;
Oxidative stress;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2021;29(8):613-618
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment (VCI) is a progressive cognitive impairment caused by cerebrovascular disease or vascular risk factors. It is the second common type of cognitive impairment after Alzheimer's disease. VCI can be caused by a variety of signal and metabolic pathways. Its core mechanism is that cerebrovascular disease destroys the neurovascular unit composed of neurons, glial cells, and cerebrovascular endothelial cells. This article summarizes and discusses the known mechanisms of VCI, in order to deepen the understanding of the molecular pathological process of VCI and provide ideas for its prevention and treatment.
