Effect of CX3CL1/CX3CR1 in cerebral ischemia and its mechanisms
10.3760/cma.j.issn.1673-4165.2021.07.011
- VernacularTitle:CX3CL1/CX3CR1在脑缺血中的作用及其机制
- Author:
Tong YANG
1
;
Qiong LI
;
Haimei YANG
;
Jie ZHU
;
Jingcheng LI
;
Lili ZHANG
Author Information
1. 中国人民解放军93046部队，青岛 266000
- Keywords:
Brain ischemia;
Chemokine CX3CL1;
CX3C chemokine receptor 1
- From:
International Journal of Cerebrovascular Diseases
2021;29(7):537-543
- CountryChina
- Language:Chinese
-
Abstract:
CX3CL1, also known as Fractalkine, is the only member of chemokines CX3C subclass. It plays an important role in a variety of central nervous system diseases and ischemic cerebrovascular diseases by binding to its specific receptor CX3CR1. In recent years, a large number of studies have investigated the specific role and related molecular mechanism of CX3CL1/CX3CR1. This article reviews the effect and molecular mechanism of CX3CL1/CX3CR1 in ischemic cerebrovascular disease, aiming to expand the understanding of the mechanism of CX3CL1/CX3CR1, and provide new ideas and intervention targets for the prevention, diagnosis and treatment of ischemic cerebrovascular disease.
