Clinical characteristics and prognosis of children with acute lymphoblastic leukemia and positive flow cytometry of cerebrospinal fluid in maintenance
10.3760/cma.j.issn.1673-4408.2021.09.013
- VernacularTitle:急性淋巴细胞白血病巩固维持期脑脊液流式细胞术阳性患儿临床特点及预后分析
- Author:
Sihan HUANG
1
;
Ranran ZHANG
;
Xiaofan ZHU
;
Wenyu YANG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所） 实验血液学国家重点实验室 国家血液病临床医学研究中心，天津 300020
- Keywords:
Children;
Acute lymphoblastic leukemia;
Cerebrospinal fluid;
Flow cytometry
- From:
International Journal of Pediatrics
2021;48(9):639-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical features and prognosis of children with positive flow cytometry of cerebrospinal fluid(CNSI + )in maintained acute lymphoblastic leukemia(ALL). Methods:Clinical data including clinical characteristics, diagnosis, treatment and prognosis of 12 patients with ALL CNSI diagnosis in maintenance period were analyzed to explore the prognostic factors.Results:The 12 children with CNSI + in maintenance were mainly male, and all of them were B-ALL.High leukemia cell count at first diagnosis( χ2=6.374, P=0.012), insensitivity to glucocorticoid pretherapy( χ2=5.048, P=0.025), increased rate of abnormal CSF cells(≥60%, χ2=7.024, P=0.008), course of CNSI + ≤14 months( χ2=4.873, P=0.027)and complex karyotype( χ2=9.356, P=0.002)are the adverse prognostic factors.Karyotype is an independent factor( P=0.017). Conclusion:The prognosis of children with CNSI + is unfavourable.Intrathecal injection and chemotherapy are the important treatment for children with CNSI + in maintenance period.Hematopoietic stem cell transplantation is an important choice for children with relapse.
