Progress of MICB/NKG2D signaling pathway in immune escape
10.3760/cma.j.issn.1673-4408.2021.09.002
- VernacularTitle:MICB/NKG2D信号通路在免疫逃逸中的研究进展
- Author:
Ang WEI
1
;
Tianyou WANG
;
Rui ZHANG
;
Zhigang LI
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院血液病中心 儿童血液病与肿瘤分子分型北京市重点实验室 儿科学国家重点学科 儿科重大疾病研究教育部重点实验室 100045
- Keywords:
Major histocompatibility complex class I polypetide-related chain;
Natural killer group 2 member D;
Immune escape;
Polymorphism
- From:
International Journal of Pediatrics
2021;48(9):584-588
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer group 2 member D(NKG2D) is an immune receptor expressed by NK cells that recognizes the human major histocompatibility complex class I polypetide-related chain(MIC) A/B on the cell surface.The interaction between NKG2D and MICA/B plays an important role in the immunosurveillance of viruses infection and cancers.In this article, we review the research progress of the MICB/NKG2D signaling pathway in immune escape including three parts: down-regulation of membrane-bound MICB, increase of secretory MICB, and polymorphism of MICB genes.
