The role of exosomes in mycobacterium tuberculosis infection and their application value
10.3760/cma.j.issn.1673-4408.2021.08.008
- VernacularTitle:外泌体在结核分枝杆菌感染中的作用及其应用价值
- Author:
Jia LIU
1
;
Yuxia SHA
;
Haoquan ZHOU
Author Information
1. 安徽医科大学附属省立医院儿科，合肥 230001
- Keywords:
Exosome;
Mycobacterium tuberculosis
- From:
International Journal of Pediatrics
2021;48(8):538-542
- CountryChina
- Language:Chinese
-
Abstract:
Mycobacterium tuberculosis(Mtb)is an intracellular bacteria that lives in the phagocytosis of host macrophages.After it invades the human body, it can cause a series of immune responses.Part of Mtb can be eliminated by the body′s immune function; some of them can survive by the immune escape mechanism and cause latent tuberculosis infection(LTBI)or tuberculosis(TB). Exosomes are extracellular vesicles with a diameter of 30-100 nm that are secreted by living cells.They are rich in proteins, lipids and nucleic acids, and exist in many body fluids of the human body.During Mtb infection, the components of exosomes released by the body can change significantly, and they can play an important role in the body′s infection and immune response, providing new ideas and theoretical basis for the prevention, diagnosis and treatment of tuberculosis infection.This article reviews the role and application value of exosomes in Mtb infection.
