Diagnosis of splenic marginal zone lymphoma
10.3760/cma.j.cn115356-20200810-00201
- VernacularTitle:脾边缘区淋巴瘤的诊断
- Author:
Weimin SUN
1
;
Jia WEI
;
Wei ZHANG
;
Xia MAO
;
Min XIAO
;
Liang HUANG
;
Jianfeng ZHOU
Author Information
1. 华中科技大学同济医学院附属同济医院血液内科，武汉 430030
- Keywords:
Lymphoma, B-cell, marginal zone;
Splenic neoplasms;
Diagnosis;
Differential diagnosis
- From:
Journal of Leukemia & Lymphoma
2021;30(6):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical features, diagnosis and differential diagnosis of splenic marginal zone lymphoma.Methods:The clinical diagnosis and differential diagnosis processes of 3 cases of CD5 - CD10 - B cell non-Hodgkin lymphoma with splenomegaly and cytopenia who were admitted to Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology in 2019 were retrospectively analyzed, and the relevant literature was reviewed. Results:The 3 cases were all elderly patients with varying degrees of splenomegaly and cytopenia. CD5 - CD10 - monoclonal B lymphocytes were found in the bone marrow or lymph nodes. Based on the patient's clinical characteristics, peripheral blood and bone marrow morphology, immunophenotype and genetic characteristics, 2 patients were diagnosed as splenic marginal zone lymphoma, and 1 patient was diagnosed as diffuse large B-cell lymphoma. Conclusions:The diagnosis of splenic marginal zone lymphoma requires comprehensive analysis of clinical characteristics, peripheral blood and bone marrow morphology, immunophenotype and genetic characteristics. Careful differentiation from other CD5 - CD10 - small B-cell lymphomas is also needed. The next-generation gene mutation high-throughput sequencing and mutational spectrum analysis will help the accurate diagnosis of atypical and difficult cases.
