Role of exosomes in the development, progression, diagnosis, and treatment of liver fibrosis
10.3969/j.issn.1001-5256.2021.12.038
- VernacularTitle:外泌体在肝纤维化发生发展及诊治中的作用
- Author:
Yehao LUO
1
;
Qiuxia CHEN
1
;
Ting LYU
2
;
Peiqi OU
1
;
Zhiyong CAO
2
;
Xuelin DUAN
1
Author Information
1. Key Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning 530200, China
2. School of Medicine, Hubei Minzu University, Enshi, Hubei 445000, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Exosomes;
Pathologic Processes;
Diagnosis;
Therapeutics
- From:
Journal of Clinical Hepatology
2021;37(12):2919-2923
- CountryChina
- Language:Chinese
-
Abstract:
An increasing number of studies have demonstrated that exosomes are closely associated with liver fibrosis and mediate the process of liver fibrosis by participating in cytokine secretion, macrophage activation, extracellular matrix remodeling, and hepatic stellate cell activation. This article summarizes that the resolution of liver fibrosis requires the reduction of pro-inflammatory and fibrotic cytokines, the reduction of extracellular matrix protein production, the increase of collagenase activity, and finally the loss of activated myofibroblasts. It is believed that exosomes play an important role in the treatment of liver fibrosis and are potential markers for diagnosis and treatment, and in future studies, it is necessary to improve exosome extraction techniques and standardization of treatment quantification.
