Bacterial outer membrane vesicles: a new approach to diseases therapy
10.16438/j.0513-4870.2021-0650
- VernacularTitle:细菌外膜囊泡: 疾病治疗的新途径
- Author:
Xiao-han QIU
1
;
Yong-jiang LI
2
;
Jun-yong WU
2
;
Jia-xin CAI
2
;
Ji-hua LIU
2
;
Wen-jie XU
2
;
Da-xiong XIANG
2
Author Information
1. Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Pharmacy, The First Affiliated Hospital of Hunan University of Medicine, Huaihua 418000, China; Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Changsha 410011, China; Institute of Clinical Pharmacy, Central South University, Changsha 410011, China
2. Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Changsha 410011, China; Institute of Clinical Pharmacy, Central South University, Changsha 410011, China
- Publication Type:Research Article
- Keywords:
outer membrane vesicle;
nanoparticle;
vaccine;
cancer immunotherapy;
rug delivery vehicle
- From:
Acta Pharmaceutica Sinica
2021;56(12):3441-3450
- CountryChina
- Language:Chinese
-
Abstract:
Outer membrane vesicles (OMVs) are nano-sized spherical vehicles, with a size range between 20-250 nm. OMVs are spontaneously secreted from Gram-negative bacteria and formed by lipid bilayer membranes, comprising multiple parent bacteria-derived components including bacterial antigens, pathogen-associated molecular patterns, proteins and lipids. OMVs have shown multiple potentials for the treatment of various diseases, including cancer therapy and bacterial infection. In this review, the structure, composition and methods for isolating and characterizing of OMVs were introduced. The applications of OMVs for diseases therapy were summarized and future perspectives were discussed.
