Research Progress of Intervention in Autoimmune Thyroid Diseases Based on Th17/ Treg Signal Axis with Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20210628
- VernacularTitle:中医药干预自身免疫性甲状腺疾病Th17/Treg平衡的研究进展
- Author:
Yan ZHANG
1
;
Min XIE
2
;
Xin-he ZUO
1
;
Yong ZHAO
1
;
Chuan HUA
1
Author Information
1. Hubei University of Chinese Medicine，Wuhan 430061，China
2. Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430074，China
- Publication Type:Research Article
- Keywords:
autoimmune thyroid disease;
helper T lymphocyte cell 17（Th17）/regulatory T lymphocyte cell （Treg）;
traditional Chinese medicine;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(10):231-238
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune thyroid disease （AITD） is a complex organ-specific autoimmune disease， associated with many factors such as genetic susceptibility， environmental factors， immune system disorders， and intestinal microbiota imbalance， which seriously affect the quality of life. At present， oral medicine， iodine 131 treatment and surgical treatment are mainly adopted in clinical parctice of western medicine. Although they can exert a certain curative effect， they still have surgical risks and side effect. Modern research shows that， traditional Chinese medicine（TCM） has the characteristics of stable curative effect， multi-targeted regulation and less side effect. It has definite efficacy and unique advantages in the prevention and treatment of AITD. Helper T lymphocyte cell 17 （Th17） mediate inflammation to induce immune promotion， while regulatory T lymphocyte cell （Treg） mediate immunosuppression， Th17 and Treg cooperate to maintain the balance of the immune microenvironment. During AITD progress， Inflammatory Th17 can be high， and the levels of mediated immunosuppressive Treg are relatively decreased. The restoration of balance between the two plays a key role in the inflammatory and immune processes of AITD. In recent years， based on Th17/Treg cell axis， a large number of clinical and experimental studies on the intervention of TCM on Th17/Treg balance in AITD have been carried out in the field of TCM， and some results have been achieved. Studies have shown that intervention in the Th17/Treg signaling axis is an important mechanism for the treatment of autoimmune thyroid diseases. This paper summarizes and analyzes the previous studies on the intervention effect of Chinese medicine monomer， Chinese medicine composition and Chinese medicine compound on Th17/Treg cell axis in AITD， mainly from the aspects of intervention related inflammatory factor secretion， regulation of antibody titer and the expression of related genes of related genes. These studies will help people to understand the mechanism of TCM in interfering with the Th17/Treg balance in AITD more accurately and comprehensively， and provide references for the rational application of TCM in the prevention and treatment of autoimmune thyroid diseases in clinical practice.
