Effect of Modified Shenfuwan on Lumbar Disc Herniation Due to Kidney Deficiency and Cold Coagulation
10.13422/j.cnki.syfjx.20210519
- VernacularTitle:加减肾附丸治疗腰椎间盘突出症肾虚寒凝证的疗效观察
- Author:
Zhong-bo ZHANG
1
;
Dong-liang SHI
1
;
Xu-zhao DU
2
;
Zhong-hua GUO
2
;
Bo-wen REN
2
;
Fu-zeng ZHENG
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
2. The Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Research Article
- Keywords:
modified Shenfuwan;
lumbar disc herniation;
kidney deficiency and cold coagulation syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(9):100-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe short-term and long-term effect of modified Shenfuwan on lumbar disc herniation due to kidney deficiency and cold coagulation. Method:100 cases were randomly divided into the control group and observation group，50 cases each. The control group were taken meloxicam tablets，7.5 mg each time，once a day and the observation group were given modified Shenfuwan，300 mL each time，twice a day. The treatment course was 3 months. The short form McGill pain questionnaire（SF-MPQ），oswestry disability index（ODI），and lumbar intervertebral disc herniation due to kidney deficiency and cold coagulation by traditional Chinese medicine （TCM ） syndrome were observed before and after treatment. Whole blood viscosity （high，medium，low），serum inflammatory factors ［tumor necrosis factor-alpha（TNF-α），interleukin-1β（IL-1β），interleukin-6（IL-6），pain mediators［endothelin-1（ET-1），prostaglandin E2（PGE2），cyclooxygenase-2（COX-2）］ were detected. The clinical efficacyand，recurrence rate followed up for 12 and 24 months was was observed. The type and time of adverse reactions were recorded during the study. Result:After treatment，the total effective rate in the observation group was 98.0%（49/50） higher than that 82.0%（41/50） in the control group（P<0.05）. After 12 months of follow-up，the recurrence rate in the observation group was 23.9%（11/46） lower than that 52.5%（21/40） in the control group （χ2＝5.193，P<0.05）. After 24 months of follow-up，the recurrence rate in the observation group was 43.9%（18/41） lower than that that 80.6%（29/36） in the control group（P<0.05）. Compared with the control group after treatment，SF-MPQ，ODI，TCM symptoms，whole blood viscosity，TNF-α，IL-1β，IL-6，ET-1，PGE2 and COX-2 were significantly reduced in the observation group（P<0.05）. The incidence of adverse reactions in the observation group was 2.0%（1/50） lower than that 52.0%（26/50） in the control group（χ2＝6.264，P<0.05）. Conclusion:Modified Shenfuwan can significantly improve the short-term and long-term clinical efficacy of patients with lumbar disc herniation due to kidney deficiency and cold coagulation syndrome，and the incidence of adverse reactions is low.
