Mechanism of Curcumin Alone and in Combination with Other Drugs Against Laryngeal Carcinoma： A Review
10.13422/j.cnki.syfjx.20211596
- VernacularTitle:姜黄素单独及联合其他药物抗喉癌作用机制研究进展
- Author:
Jing-han DENG
1
;
Yuan-xin HU
1
;
Jing CHEN
1
;
Yao HOU
1
;
Rong PEI
2
;
Chun-lian WU
1
Author Information
1. Key Laboratory of Southwest China Wildlife Resource Conservation of Ministry of Education， China West Normal University， Nanchong 637009， China
2. School of Public Health， Chengdu University of Traditional Chinese Medcine， Chengdu 610075， China
- Publication Type:Research Article
- Keywords:
curcumin;
laryngeal carcinoma （LC）;
anti-tumor;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(15):235-242
- CountryChina
- Language:Chinese
-
Abstract:
Curcumae Longae Rhizoma is a traditional Chinese medicine with the efficacy of activating blood and moving Qi. Curcumin， a polyphenolic substance extracted from the rhizome of plant Curcuma longa， possesses multiple pharmacological activities like anti-tumor， anti-oxidation， anti-bacteria， and anti-inflammation. Laryngeal carcinoma （LC） is a common malignant tumor， whose incidence in recent years has been on the rise， and the 5-year survival rate has continuously decreased. Considering the specific location of larynx， researchers are actively exploring diverse treatment modalities for laryngeal organ preservation. Many studies have shown that curcumin has an inhibitory effect on the development of LC. By virtue of multiple pharmacological effects， curcumin deserves to be thoroughly explored. However， most of the current research is limited to in vitro exploration， and the partial mechanism of curcumin remains unclear， indicating that there is still a long way to go before curcumin becomes a Chinese medicinal preparation for the clinical treatment of LC. This paper reviewed the physicochemical properties of curcumin and the methods for its extraction from plants， the efficacy of curcumin in inducing cell apoptosis and protective autophagy， reversing cell drug resistance， inhibiting cell proliferation， migration， and invasion and tumor angiogenesis， the action mechanism of curcumin in combination with resveratrol， platinum drugs， 3-methyladenine， taxols， and 5-fluorouracil against LC， as well as the bioinformatics analysis concerning curcumin and LC. This paper is expected to provide reference for relevant researchers to clarify the mechanism and important targets of curcumin against LC and promote its clinical application.
