Postoperative Survival of Triple Negative Breast Cancer Patients After High Exposure to Traditional Chinese Medicine： A Cohort Study
10.13422/j.cnki.syfjx.20211493
- VernacularTitle:高暴露中药治疗对三阴性乳腺癌术后生存的影响
- Author:
Xiao-qiu MA
1
;
Dong-feng YIN
2
;
Hong GAO
1
;
Yu-zhen PAN
1
Author Information
1. Liaoning University of Traditional Chinese Medicine，Shenyang 110000，China
2. The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110000，China
- Publication Type:Research Article
- Keywords:
triple negative breast cancer （TNBC）;
disease free survival （DFS）;
retrospective cohort study;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(14):99-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the 3-year survival outcomes of postoperative patients after high exposure to traditional Chinese medicine （TCM） for triple negative breast cancer （TNBC）. Method:The complete 3-year follow-up data of 150 postoperative patients with stage I–III TNBC were retrospectively analyzed. All the patients received routine western medical treatments （surgery， chemotherapy， and/or radiotherapy） according to the National Comprehensive Cancer Network （NCCN） clinical practice guidelines in oncology as well as TCM. According to the degree of exposure to TCM， they were divided into the high- and low-exposure cohorts， with the oral administration of Chaihu Longmu Decoction with or without anti-cancer Chinese patent medicine for at least six months annually， or 18 months or more in the three years as the inclusion criterion for the former cohort. The metastatic sites of recurrent TNBC and the recurrent metastasis/death time were observed in both cohorts to compare the disease-free survival （DFS） and overall survival （OS）. The influences of onset age， pathological type， histopathological grade， vascular invasion， clinical stage， and exposure to TCM on survival were subjected to statistical analysis， followed by the observation of adverse effects. Result:There was no significant difference in the metastatic sites between the two cohorts （P>0.05）. The high-exposure cohort had a longer 3-year DFS than the low-exposure cohort， and the 3-year DFS rate in the high-exposure cohort was increased by 16.9% （χ2=6.995， P=0.008） as compared with that in the low-exposure cohort， exhibiting a significant difference （P<0.05）. As revealed by the Cox proportional-hazards model， patients in the low-exposure cohort had a 3.724-fold as high risk of recurrent metastasis as that in the high-exposure cohort （95%CI 1.399~9.915）. There was no significant difference in the 3-year OS between the two cohorts （P>0.05）. The overall incidence of adverse effects in both groups was 7.3%， mainly manifested as gastrointestinal discomfort. Conclusion:High exposure to TCM contributes to reducing postoperative recurrence and metastasis and prolonging DFS.
