Data Mining-Based Macroscopic Exploration of Clinical Medication of Chinese Medicine for Liver Cancer
10.13422/j.cnki.syfjx.20210814
- VernacularTitle:基于数据发掘探寻肝癌中医临床用药的宏观规律
- Author:
Ya-gang SONG
1
;
Ming BAI
1
;
Lin-lin CUI
1
;
Yan LI
1
;
Li-ling XIANG
1
;
Le KANG
1
;
Ming-san MIAO
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
primary liver cancer;
traditional Chinese medicine （TCM） clinical practice;
medication law;
high-frequency drugs;
cluster analysis;
clinical syndromes
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(13):146-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the macroscopic medication rule of Chinese medicine for the treatment of primary liver cancer and provide references for clinical medication. Method:The databases of CNKI，VIP， and Wanfang Data were searched for research articles published from September 1959 to June 2019 with the terms of "Chinese medicine" and "liver cancer". A database was established based on the collected Chinese medicinal prescriptions for the treatment of primary liver cancer. The frequency，clustering， and association rules were analyzed by Excel， etc. Result:In this study，106 effective articles were included，and after the modified prescriptions were removed， 92 effective prescriptions were screened out，involving 281 Chinese herbal medicines used for 1 181 times in total. The top 5 high-frequency drugs were Poria （deficiency-tonifying），Astragali Radix （heat-clearing），Bupleuri Radix （blood-activating and stasis-resolving），Paeoniae Radix Alba （urination-promoting and dampness-draining）， and Codonopsis Radix （Qi-regulating）. The analysis of drug flavor with a frequency higher than 10 showed that most of the drugs were sweet，bitter， and pungent in flavor，cold，warm， and plain in nature，and acted on spleen and liver meridians. Four combinations and 10 herbal pairs were obtained by the cluster analysis of high-frequency drugs and association analysis， respectively. The high-frequency drugs and potential herbal pairs were classified targeting the specific clinical syndromes in different stages of liver cancer. Conclusion:Replenishing Qi， invigorating spleen，clearing heat， removing toxin，activating blood， and resolving stasis were the basic principles for the treatment of primary liver cancer. The combination of those drugs was the main therapeutic strategy. In addition，the resulting 10 potential herbal pairs from high-frequency drugs and cluster analysis could inspire the clinical treatment of primary liver cancer in different clinical stages with various clinical syndromes， which was of reference value for the clinical medication.
