Effect of Modified Shuzhong Huatantang Replace Hormone on Children with Chronic Rhinosinusitis and Adenoid Hypertrophy due to Spleen Deficiency and Phlegm Obstruction After Operation
10.13422/j.cnki.syfjx.20210116
- VernacularTitle:加减舒中化痰汤替代激素治疗慢性鼻-鼻窦炎合并腺样体肥大患儿术后的临床疗效
- Author:
Jing-bo LI
1
;
Jue-jie WANG
1
;
Ji-tang CAI
1
;
Ling-min ZHANG
1
;
Hui-min WANG
1
;
Wen-ming CHEN
1
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Research Article
- Keywords:
modified Shuzhong Huatantang;
chronic rhinosinusitis;
adenoid hypertrophy;
spleen deficiency and phlegm obstruction
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(2):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of modified Shuzhong Huatantang replace hormone on children with rhinosinusitis and adenoid hypertrophy due to spleen deficiency and phlegm obstruction after operation. Method:Eighty cases were randomly divided into control group and observation group，40 cases in each group. After nasal endoscopy，the control group was given mometasone furoate，and the observation group was given modified Shuzhong Huatantang for 6 week. The nasal situation Lund-Kennedy assessment scal（Lund-Kennedy），adenoid thickness /nasopharyngeal cavity width （A/N），TCM syndrome were observed for before treatment，6，24，and 48 weeks after operation. The contents of immunoglobulin E（IgE），eosinophilic cationic protein（ECP），eosinophilic granulocyte（EOS），tumor necrosis factor-alpha（TNF-α），interleukin-1β（IL-1β），interleukin-17（IL-17） in serum and nasal secretions were detected before and 48 weeks after operation. The clinical efficacy，complications，recurrence 48 weeks after operation were compared between the two groups. Result:Three cases of abscission in the control group and one case in the observation group during the study period. The total control rate was 94.9% in the observation group higher than that 75.7% in the control group six weeks after the operation（χ2=6.972，P<0.05）. The recurrence rate was 2.6% in the observation group lower than that 18.9% in the control group 48 weeks after operation（χ2=4.137，P<0.05）. To compared with the control group at 6，24 and 48 weeks after operation，Lund-Kennedy，A/N，TCM syndromes in the observation group decrease in the same period （P<0.05）. To compared with the control group 48 weeks after operation，The TNF-α，IL-1β，IL-17，IgE，ECP，EOS in serum and nasal secretions in the observation group were reduced （P<0.05）. The incidence of adverse reactions was 2.7% in the observation group lower than that 29.7% in the control group. Conclusion:Modified Shuzhong Huatantang can significantly improve the postoperative clinical symptoms with chronic rhinosinusitis and adenoid hypertrophy due to spleen deficiency and phlegm obstruction，and the recurrence rate is lower.
