Clinical Effect of Tiaomai Mixture on Premature Ventricular Contraction in Coronary Heart Disease Due to Qi-Yin Deficiency and Stagnated Heat in Blood Vessel
10.13422/j.cnki.syfjx.20210316
- VernacularTitle:调脉合剂治疗气阴两虚兼血脉瘀热型冠心病室性期前收缩的临床疗效分析
- Author:
Yao HAN
1
;
Mei DAI
1
;
Hong-xu LIU
1
;
Da-wei ZHANG
1
;
Zhi-zhen WEI
1
Author Information
1. Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing 100010，China
- Publication Type:Research Article
- Keywords:
Tiaomai mixture;
premature ventricular contraction;
cooling blood and clearing heat;
heart rate variability;
hypersensitive C-reactive protein
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):118-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effect of Tiaomai mixture combined with metoprolol tartrate on premature ventricular contraction in coronary heart disease （CHD） due to Qi-Yin deficiency and stagnated heat in blood vessel. Method:A total of 95 patients with CHD complicated with premature ventricular contraction were randomized into a treatment group and a control group. Four cases dropped out， leaving 91 cases （45 in the treatment group and 46 in the control group） included in the follow-up. On the basis of routine treatments for CHD， patients in the control group were further treated with metoprolol tartrate， while those in the treatment group received metoprolol tartrate plus Tiaomai mixture. Such curative effect and safety indexes as traditional Chinese medicine （TCM） syndrome score， electrocardiogram （ECG）， and 24 h dynamic ECG were observed before and after four-week treatment. Result:After treatment， the therapeutic effect on arrhythmia in the treatment group was better than that in the control group（P<0.05）. The treatment group was superior to the control group in reducing the frequency of premature ventricular contraction （P<0.05）， improving the Lown grade （P<0.01）， increasing the heart rate variability index （P<0.05）， and ameliorating the QT dispersion in ECG （P<0.05）， hypersensitive C-reactive protein， and homocysteine（P<0.05）. As revealed by comparison with those before treatment， both interventions improved TCM syndrome， with better outcomes observed in the treatment group （P<0.01）， manifested as the alleviation of shortness of breath， fatigue， dry mouth with desire to drink， and tongue and pulse manifestations （P<0.01）. Conclusion:Tiaomai mixture improves the clinical efficacy against arrhythmia in CHD patients by regulating the heart rate variability index， inhibiting inflammatory cytokines， lowering homocysteine， and relieving clinical symptoms， which is worthy of clinical promotion and application.
