Effect of Fluid Sheer Stress on Atherosclerosis and Progress of Research on Treatment of Sheer Stress Injury with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20210723
- VernacularTitle:剪切力对动脉粥样硬化的影响及中药抗剪切力损伤的研究进展
- Author:
Lei ZHANG
1
;
Jia-li LIU
1
;
Lin LIN
1
;
Chao LI
1
;
Yun-lun LI
1
;
Wen-qing YANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250355，China
- Publication Type:Research Article
- Keywords:
atherosclerosis（AS）;
shear stress;
endothelial function;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(18):234-242
- CountryChina
- Language:Chinese
-
Abstract:
Cells in the arterial wall are constantly subjected to the shear stress generated by the blood flow. Shear stress plays a pivotal role in the formation of atherosclerosis. The endothelial cells located between the blood and the vessel wall have a unique response to the shear stress of the blood flow， which can convert mechanical stimulation into intracellular signals， thereby affecting the pathological process of atherosclerosis. Endothelial function is not only regulated by hormones， growth factors and other biochemical substances， but also affected by mechanical forces such as blood flow shear stress. Physiologically， shear stress can play an anti-atherosclerotic role in maintaining the homeostasis of endothelial cells. Pathological shear stress will lead to endothelial dysfunction and promote the progression of atherosclerosis. Under the mediation of different shear stress， the endothelial function can be regulated through epigenetic pathways or mechanically sensitive cation channels. Therefore， it is necessary to understand how various signal transduction pathways are affected by pathological shear stress， so as to cause endothelial dysfunction and atherosclerosis. Traditional Chinese medicine（TCM） has been increasingly recognized for its curative effect in treating atherosclerosis， with the advantages of few side effects， multiple targets and multiple mechanisms. In recent years， the understanding of the anti-atherosclerosis mechanism of TCM mediated by shear stress has gradually deepened. This review will take endothelial function as the breakthrough point， systematically sort out the influence of shear stress on the pathological process of atherosclerosis and the related molecular mechanisms. Meanwhile， it is the first time to summarize the latest research progress of Chinese medicine against shear stress damage by sorting out the existing literature. This article mainly clarify the relationship between shear stress， endothelial function， atherosclerosis and TCM， in order to provide a theoretical basis for the clinical treatment and pathological mechanism of atherosclerosis.
