Action Mechanisms of Zhongjing's Antidepressant Prescriptions： A Review
10.13422/j.cnki.syfjx.20212436
- VernacularTitle:抗抑郁仲景方药的作用机制研究进展
- Author:
Li-zhi SHANG
1
;
Yao-yang LI
1
;
Wen-ying XIE
1
;
Rui-qin LI
1
Author Information
1. Academy of Chinese Medical Sciences， The First Clinical School， College of Traditional Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
depression;
Zhongjing's prescriptions;
multiple targets;
pathogenesis;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(24):25-32
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a threat to human health due to high incidence， recurrence， and disability rates. At present， the complex etiology and pathogenesis of depression are still unclear， and such hypotheses as monoamine neurotransmitters and their receptor abnormality， hyperactivity of hypothalamic-pituitary-adrenal （HPA） axis， inflammation， and neuron damage and remodeling have been put forward. Anti-depressants developed based on the pathogenesis have a certain effect， but there also exist some problems like low cure rate， poor compliance， relapse after discontinuation， and obvious side effects. According to Zhongjing's theory， depression falls into the categories of depression syndrome， visceral agitation， insomnia， and lily disease， and it is mainly located in the liver， involving the spleen， heart， and kidney. The pathogenesis mainly lies in qi stagnation and zang-fu organ dysfunction. Attention should be focused on regulating qi and relieving depression. Zhongjing's antidepressant prescriptions have exhibited good clinical efficacy in the treatment of depression， reflecting the multi-pathway action advantages of Chinese herbs. Based on the pathogenesis of depression and domestic and foreign literature on the intervention of depression with Zhongjing's prescriptions available in the past 20 years， this paper summarized the mechanisms of Zhongjing's prescriptions against depression from the experimental and clinical research aspects， in order to provide reference for clinical treatment of depression with Zhongjing's prescriptions.
