Effect and Mechanism of Qixian Tongluo Prescription on Neural Function Recovery in Patients with Cerebral Infarction
10.13422/j.cnki.syfjx.20212395
- VernacularTitle:芪仙通络方对脑梗死恢复期患者神经功能恢复的影响及机制
- Author:
Xiu-hui LIN
1
;
Zhi-min WU
1
;
Yi-ru WANG
1
;
Fang LIU
2
Author Information
1. Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University，Wenzhou 325000，China
2. Liu Zu-yi Inheritance Studio，Master of National Medicine，The Affiliated Hospital of Hunan Academy of Chinese Medicine in Hunan Province，Changsha 410006，China
- Publication Type:Research Article
- Keywords:
convalescence of cerebral infarction;
Qixian Tongluo prescription;
warming yang and promoting blood circulation;
neural repair;
brain-derived neurotrophic factor（BDNF）;
vascular endothelial growth factor（VEGF）;
stromal cell-derived factor-1（SDF-1）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(23):118-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of Qixian Tongluo prescription on neural function recovery in patients with cerebral infarction and its mechanism. Method:A total of 100 inpatients （January to June，2020）with cerebral infarction in the Neurology Department of Wenzhou Hospital of Traditional Chinese Medicine were assigned to an experimental group （n=50） and a control group （n=50） according to the random number table. Both groups received conventional treatment of western medicine，while the experimental group took additional Qixian Tongluo prescription. Treatment lasted for 12 weeks. The clinical efficacy，National Institutes of Health Stroke Scale （NIHSS） score， the modified Barthel index （MBI），Fugl-Meyer assessment （FMA） score， and levels of brain-derived neurotrophic factor（BDNF），vascular endothelial growth factor（VEGF）， and stromal cell-derived factor-1（SDF-1） in peripheral blood of the two groups before and after treatment were compared. Result:The total response rate in the experimental group was 84.00%（42/50），higher than 66.00%（33/50） in the control group （Z=-7.365，P<0.05）. There was no significant difference in the scores of MBI，FMA， and NIHSS before treatment between the two groups. The MBI and FMA scores of the two groups increased （P<0.01）， and the NIHSS scores decreased （P<0.05， P<0.01）. Compared with the control group after treatment， the experimental group showed increased MBI and FMA scores and decreased NIHSS score （P<0.05）. There was no significant difference in BDNF level between the two groups before and after treatment. The VEGF and SDF-1 levels in the peripheral blood of the two groups were higher than those before treatment （P<0.05）， and the experimental group was higher than the control group （P<0.05）. Conclusion:Qixian Tongluo prescription can effectively improve the clinical efficacy，the quality of life， and the prognosis of patients with cerebral infarction during convalescence. The underlying mechanism is associated with the promotion of the expression of endogenous VEGF and SDF-1 in the peripheral blood to activate the SDF-1/chemokine receptor 4（CXCR4） signaling pathway， induce the recruitment and mobilization of endothelial progenitor cells， and facilitate the angiogenesis and repair of ischemic brain tissues.
