Role of Kelch-like ECH-associated Protein-1-Nuclear Factor Erythroid 2-related Factor-2/Antioxidant Responsive Element Signal Pathway for Multiple Sclerosis (review)
10.3969/j.issn.1006-9771.2020.03.013
- VernacularTitle:Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展
- Author:
Ling-ling SU
1
;
Bi-e ZHENG
1
;
Jin-di HE
1
;
Jian-zhong FAN
1
;
Rui-xue YIN
1
Author Information
1. Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University,Guangzhou,Guangdong 510515,China
- Publication Type:Research Article
- Keywords:
multiple sclerosis;
oxidative stress;
Kelch-like ECH-associated protein-1;
nuclear factor E2-related factor-2;
antioxidant responsive element;
signal pathway;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(3):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Multiple sclerosis (MS) is a chronic inflammatory disease, mainly due to the activation of the T cells, which makes oxidative stress reaction in brain and leads to demyelination finally. Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor-2 (Nrf2)/antioxidant responsive element (ARE) signal pathway is one of the most important endogenous antioxidant pathways, which promotes the expression of detoxification enzymes and antioxidant protein to eliminate oxygen free radicals and balance intracellular redox system. Activation of the Keap1-Nrf2/ARE may delay the progression of MS by drugs or rehabilitation.
