Effects of Electroacupuncture on White Matter Fibers and Learning-memory Function in Rats with Vascular Dementia
10.3969/j.issn.1006-9771.2020.03.011
- VernacularTitle:电针对血管性痴呆大鼠脑白质纤维和学习记忆功能的效果
- Author:
Bing-xue ZHANG
1
;
Min-guang YANG
1
;
Jian-hong LI
1
;
Jing TAO
1
;
Sheng-xiang LIANG
2
;
Wei-lin LIU
1
;
Li-dian CHEN
1
Author Information
1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian350122,China
2. National & Local Joint Engineering Research Center of Rehabilitation Medical Technology, Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian350122,China
- Publication Type:Research Article
- Keywords:
vascular dementia;
electroacupuncture;
white matter fiber;
diffusion tensor imaging;
learning and memory;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(3):319-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of electroacupuncture at Baihui (DU20) and Shenting (DU24) acupoints on white matter fiber and learning-memory function in rats with vascular dementia (VD). Methods:Sprague-Dawley rats were randomly divided into operation group and sham group (n = 8). The operation group accepted two-vessel occlusion, while the sham group only separated the bilateral common carotid arteries without ligation. The rats modeled successfully were randomly divided into model group (n = 8), non-acupoint group (n = 8) and electroacupuncture group (n = 8). The electroacupuncture group accepted electroacupuncture at Baihui and Shenting, and the non-acupoint group accepted electroacupuncture at axillary non-acupoint, once a day for 28 days. All the rats were tested with object recognition test before and after intervention, while the white matter fibers were observed with Diffusion Tensor Imaging. Results:Compared with the sham group, the preference coefficients of the model group, the non-acupoint group and the electroacupuncture group decreased before intervention (P< 0.05), and there was no significant difference among the later three groups (P> 0.05). The preference coefficients increased in the electroacupuncture group compared with the model group after intervention (P< 0.05). The fractional anisotropy (FA) of corpus callosum, cingulate gyrus and hippocampus decreased in the model group, the non-acupoint group and the electroacupuncture group compared with the sham group before intervention. FA of hippocampus, cingulate gyrus, corpus callosum and external capsule increased in the electroacupuncture group compared with the model group after intervention. Conclusion:Electroacupuncture at Baihui and Shenting can improve learning-memory function of VD rats, which may be related with repairment of white matter fibers in prefrontal cortex, hippocampus and others.
