Advance in Role of Mitochondrial Quality Control in Exercise for Sarcopenia (review)
10.3969/j.issn.1006-9771.2020.09.012
- VernacularTitle:运动通过调控线粒体质量控制改善肌少症的研究进展
- Author:
Cen-yi WANG
1
;
Ji-ling LIANG
2
;
Yu-hao SI
3
;
Ning CHEN
4
Author Information
1. Soochow University School of Sport, Suzhou, Jiangsu 215021, China
2. Graduate School, Wuhan Sports University, Wuhan, Hubei 430079, China
3. John G. Rangos Sr. School of Health Sciences, Duquesne University, Pittsburgh, PA15282, USA
4. Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan, Hubei 430079, China
- Publication Type:Research Article
- Keywords:
sarcopenia;
mitochondrial quality control;
exercise intervention;
mitophagy;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2020;26(9):1066-1070
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is a process in which skeletal muscle mass and strength are gradually declining, resulting a main health challenge for the old adults. Mitochondria can maintain the integrity of structure and function of skeletal muscle by improving biosynthesis, antioxidant defense, fusion/fission dynamics and mitophagy. Mitochondrial dysfunction is a important factor leading to the complex etiology of sarcopenia. Exercise can regulate mitochondrial quality control pathways by activating mitochondrial biogenesis and mitophagy to maintain optimal mitochondrial function, thereby delaying and preventing the onset and progression of sarcopenia.
