Experimental Advance in Seed Cells and Biological Scaffolds for Spinal Cord Tissue Engineering (review)
10.3969/j.issn.1006-9771.2021.06.008
- VernacularTitle:种子细胞与生物支架在脊髓组织工程中的实验研究进展
- Author:
Guo-dong QI
1
;
Qiong JIANG
2
;
Ya-min WU
3
;
Wei QI
1
Author Information
1. Orthopedic Department, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, Chongqing 400010, China
2. Chongqing Medical University, Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing 400016, China
3. Field Surgery Research Institute, Daping Hospital, PLA Military Medical University, State Key Laboratory of Trauma Burn and Complex Injury, Chongqing 400042, China
- Publication Type:Research Article
- Keywords:
spinal cord tissue engineering;
spinal cord injury;
seed cells;
biological scaffolds;
experiment research;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2021;27(6):677-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the problems of seed cells and biological scaffolds in spinal cord tissue engineering, and review the recent experimental research. Methods:Related literatures were searched in CNKI, Wangfang data, PubMed and Web of Science from establishment to March, 2021, and the problems and progress of seed cells, biological scaffolds and their combination were reviewed. Results:The problems of seed cells are carcinogenicity, immune rejection, ethics, low survival rate and differentiation rate after transplantation, and current researches focus on exploring new cell types, gene transfection, cell co-transplantation and pretreatment before transplantation. The problems of biological scaffold are that a single material selection cannot meet different needs, and the traditional technology cannot simulate the internal structure of spinal cord well. There were more researches focusing on new composite materials and new technology. The core problem of their combination is that the effects of different cell and scaffold combinations are different, and the current researches are mostly devoted to the continuous exploration of suitable composite mode, and try to introduce biological agents and other factors. Conclusion:Spinal cord tissue engineering has the potential to completely change the therapeutic pathway of spinal cord injury. Current experimental researches mainly base on solving the problems of seed cells and biological scaffolds of spinal cord tissue engineering, and further explore the appropriate composite mode of seed cells and biological scaffolds, so as to provide more basic evidence for its clinical application.
